Plasma Membrane Calcium ATPase (PMCA): A novel drug target and biomarker for neurodegenerative diseases

Target Name: Plasma Membrane Calcium ATPase

NCBI ID: P12403

Plasma Membrane Calcium ATPase

Other Name(s): PMCA

Plasma Membrane Calcium ATPase (PMCA): A novel drug target and biomarker for neurodegenerative diseases

Abstract:

Plasma membrane calcium ATPase (PMCA) is a highly conserved transmembrane protein that plays a crucial role in various physiological processes, including intracellular signaling, neurotransmission, and neuroprotection. The PMCA gene has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In this article, we review the current research on PMCA, its functions, and potential as a drug target or biomarker.

Introduction:

PMCA is a transmembrane protein that is primarily located in the plasma membrane of various cell types. It is a key regulator of intracellular signaling and neurotransmission, maintaining the balance of calcium ions in the cytosol, which plays a crucial role in intracellular signaling and neurotransmission. PMCA has also been shown to play a role in neuroprotection, ensuring the survival of neurons and maintaining the integrity of the nervous system.

PMCA functions:

PMCA plays a critical role in intracellular signaling, particularly in the regulation of neurotransmitter release and neurotransmission. It is involved in the regulation of neurotransmitter release by activating the cAMP-dependent protein kinase (PKA) and the adenylyl cyclase (AC). PMCA has also been shown to play a role in neurotransmission by regulating the release of neurotransmitters, such as dopamine and serotonin, and by modulating the activity of neurotransmitter receptors.

PMCA is also involved in the regulation of ion channels, including the Na+, K+, and Ca2+ channels. The PMCA channel is a critical regulator of the Ca2+ ions, ensuring the proper balance of calcium ions in the cytosol, which is essential for intracellular signaling and neurotransmission.

PMCA is also involved in the regulation of cellular signaling pathways, including cell adhesion, migration, and survival. PMCA has been shown to play a role in the regulation of cell adhesion by activating the 尾2 integrin protein and the cadherin protein. PMCA has also been shown to play a role in the regulation of cell migration by regulating the activity of the myosin protein.

PMCA is also involved in the regulation of neuroprotection, ensuring the survival of neurons and maintaining the integrity of the nervous system. PMCA has been shown to play a role in neuroprotection by regulating the production of reactive oxygen species (ROS), which can damage cellular components and contribute to the development of neurodegenerative diseases.

PMCA as a drug target:

PMCA has been identified as a potential drug target for various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. The PMCA gene has been shown to be mutated in various neurodegenerative diseases, including Alzheimer's disease, and these mutations have been shown to play a role in the development of neurodegenerative diseases.

PMCA has also been shown to interact with various drug targets, including the tyrosine kinase receptor (TKR), the G protein-coupled receptor (GPCR), and the nuclear factor kappa B (NFKB). These interactions may provide a potential mechanism for the efficacy of certain drugs, such as those that target these drug targets, in the treatment of neurodegenerative diseases.

PMCA as a biomarker:

PMCA has also been used as a biomarker for various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The levels of PMCA have been shown to be decreased in the brains of individuals with Alzheimer's disease and Parkinson's disease, and these decreases have been associated with the progression of these diseases. Additionally, PMCA has

Protein Name: Plasma Membrane Calcium ATPase (nonspecified Subtype)

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•   its importance;
•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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